Update on Phytomedicines Medicinal Plants and Phytomedicines. Linking Plant Biochemistry and Physiology to Human Health

The past decade has witnessed a tremendous resurgence in the interest and use of medicinal plant products, especially in North America. Surveys of plant medicinal usage by the American public have shown an increase from just about 3% of the population in 1991 to over 37% in 1998 (Brevoort, 1998). The North American market for sales of plant medicinals has climbed to about $3 billion/year (Glaser, 1999). Once the domain of health-food and specialty stores, phytomedicines have clearly re-emerged into the mainstream as evidenced by their availability for sale at a wide range of retail outlets, the extent of their advertisement in the popular media, and the recent entrance of several major pharmaceutical companies into the business of producing phytomedicinal products (Brevoort, 1998; Glaser, 1999). No doubt a major contributing factor to this great increase in phytomedicinal use in the United States has been the passing of federal legislation in 1994 (Dietary Supplement Health and Education Act or “DSHEA”) that facilitated the production and marketing of phytomedicinal products (Brevoort, 1998). The past decade has also witnessed intense interest in “nutraceuticals” (or “functional foods”) in which phytochemical constituents can have long-term health promoting or medicinal qualities. Although the distinction between medicinal plants and nutraceuticals can sometimes be vague, a primary characteristic of the latter is that nutraceuticals have a nutritional role in the diet and the benefits to health may arise from long-term use as foods (i.e. chemoprevention) (Korver, 1998). In contrast, many medicinal plants exert specific medicinal actions without serving a nutritional role in the human diet and may be used in response to specific health problems over shortor long-term intervals. For many of the medicinal plants of current interest, a primary focus of research to date has been in the areas of phytochemistry, pharmacognosy, and horticulture. In the area of phytochemistry, medicinal plants have been characterized for their possible bioactive compounds, which have been separated and subjected to detailed structural analysis. Research in the pharmacognosy of medicinal plants has also involved assays of bio-activity, identification of potential modes of action, and target sites for active phytomedicinal compounds. Horticultural research on medicinal plants has focused on developing the capacity for optimal growth in cultivation. This has been especially pertinent as many medicinal plants are still harvested in the wild, and conditions for growth in cultivation have not been optimized. Wild harvesting of medicinal plants can be problematic in terms of biodiversity loss, potential variation in medicinal plant quality, and occasionally, improper plant identification with potential tragic consequences. From the perspective of plant physiology, extensive opportunities exist for basic research on medicinal plants and the study of their phytomedicinal chemical production. This review presents a discussion on some fundamental aspects of phytomedicinal chemical production by plant cells with an overview of several medicinal plants that have received considerable use and attention over the past decade.